
Biopharma
FlowCam for Protein Aggregate Analysis in Therapeutics Development
Discover a high-throughput flow imaging microscopy platform for characterizing API aggregates and other particulates in your protein, monoclonal antibody, or antibody-drug conjugate formulation.
Monitor your formulation for protein aggregates, intrinsic particles including silicone oil, degraded polysorbate, and glass flakes, as well as extrinsic contaminants.
FlowCam provides quality assurance for your parenteral drug product to give you peace of mind about the stability and safety of your formulation.
Use FlowCam to:
- Count and size protein aggregates as small as 300 nm with industry-leading image quality
- Obtain complementary particle image data recommended by USP <1788> to verify orthogonal particle size measurements by light obscuration
- Utilize image-based analytics including artificial intelligence tools to classify subvisible and submicron particles
Helpful Resources
“With FlowCam we get to see the particle morphology instead of just counts, and that really helps facilitate the debugging process if we encounter any issues during the development of new products.”

A FlowCam collage of common particles in therapeutic protein formulations including protein aggregates, silicone oil droplets, and polysorbate particles.

The FlowCam family of products for biopharmaceutical applications: FlowCam 8100, FlowCam Nano, FlowCam LO

VisualSpreadsheet software interface showing protein aggregates automatically identified with VisualAI artificial intelligence.
FlowCam Provides Confidence in Protein Formulation Quality
Capture high-resolution images for the identification of particle type, allowing you to detect and mitigate undesirable and potentially harmful particle formation at the source.
Improve formulation design based on protein aggregate analysis using FlowCam in accelerated protein stability studies.
- Use FlowCam LO to obtain USP <787> compendial particle sizing information and images in a single instrument in quality control monitoring
- Improve lab productivity and data reproducibility with ALH for FlowCam automated liquid handling.
- Employ VisualAI™ to classify images of protein biotherapeutics automatically with higher than 90% accuracy
Additional Resources
Guides
- Advancing Subvisible Particle Analysis: Flow Imaging Microscopy
- Ultimate Guide to Flow Imaging Microscopy for Biotherapeutics
Blog Posts
- What are the USP <787>, USP <788>, and USP <789> Standards?
- What are the Recommendations in USP <1787> and <1788>?
- What Does "Orthogonal Method" Mean for Particle Analysis?
- What's the Value of Monitoring Silicone Oil Droplets in Protein Therapeutics?
Videos
Application Notes
Published Research

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