Particle Size and Shape Analysis using Flow Imaging Microscopy

Flow Imaging Infographic - updated

A flow imaging particle analyzer performs three functions all in one instrument:

  1. Examines a fluid under a microscope
  2. Takes images of the magnified particles within that fluid
  3. Characterizes the particles using a variety of measurements

The fluidics system uses an ultra-high-precision computer controlled syringe pump to pull the fluid sample through a flow cell perpendicular to the optical path.

The optical system is similar to a microscope, and is used to capture real-time images of the particles in the fluid as they pass through the flow cell. Additional optional electronics allow FlowCam to capture particle images when a fluorescence signal is detected in the flow cell.

The Benefits of Flow Imaging Microscopy

see-whats-under-the-curveThe FlowCam flow imaging cytometer and particle analyzer gives you more detailed, more accurate results than traditional volumetric techniques like flow cytometry, laser diffraction, and light obscuration. 

Most particle analyzers and particle counters provide only a distribution of particle size. The FlowCam gives you over 40 different measurements for each particle, as quickly as the other systems give you only one measurement – size.

While particle size distributions alone may be sufficient when looking at a uniform, homogenous sample of material, in the real world most of your samples contain different types of particles. And you typically want to find out how many of each particle type your sample contains.  

You need more than just size data to properly distinguish one particle type from another. Especially when other volumetric techniques convert particle size to equivalent spherical diameter. With VisualSpreadheet® software you collect particle shape (morphology) measurements as well as gray-scale measurements (transparency, intensity, etc.) and color information (optionally) to enable you to better characterize the particle in your sample. 

FlowCam also offers more advanced shape measurements – including circularity, convexity, fiber curl, and symmetry – which help you distinguish between particle types that may have almost identical sizes.

What is Flow Imaging Microscopy?

 

FlowCam Explainer Video - Ebook - 1080p

 

 

Learn more about the benefits in our informative e-Book, The Ultimate Guide to Flow Imaging Microscopy.

Download eBook: Ultimate Guide to Flow Imaging Microscopy

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